The Center for Muslim-Christian Understanding was founded in 1993 by an agreement between the Fondation pour L'Entente entre Chretiens et Musulmans, Geneva and Georgetown University to build stronger bridges of understanding between the Muslim world and the West as well as between Islam and Christianity. The Center's mission is to improve relations between the Muslim world and the West and enhance understanding of Muslims in the West. The geographic scope and coverage of the center includes the breadth of the Muslim world, from North Africa to Southeast Asia, as well as Europe and America. Since its foundation, the Center has become internationally recognized as a leader in the field of Muslim-Christian relations.
In December 2005, the Center for Muslim-Christian Understanding (CMCU) received a $20 million dollar gift from HRH Prince Alwaleed Bin Talal, an internationally renowned businessman and global investor, to support and expand the Center for Muslim-Christian Understanding. The Center was renamed the Prince Alwaleed Bin Talal Center for Muslim-Christian Understanding (ACMCU). This endowed fund was the second largest single gift in Georgetown University history.